Multicategory Angle-Based Learning for Estimating Optimal Dynamic Treatment Regimes With Censored Data

New Statistical Learning Methods for Estimating Optimal Dynamic Treatment Regimes.

Dynamic treatment regimes (DTRs) are sequential decision rules for individual patients that can adapt over time to an evolving illness. The goal is to accommodate heterogeneity among patients and find the DTR which will produce the best long term outcome if implemented. We introduce two new statistical learning methods for estimating the optimal DTR, termed backward outcome weighted learning (B...

Doubly Robust Learning for Estimating Individualized Treatment with Censored Data.

Individualized treatment rules recommend treatments based on individual patient characteristics in order to maximize clinical benefit. When the clinical outcome of interest is survival time, estimation is often complicated by censoring. We develop nonparametric methods for estimating an optimal individualized treatment rule in the presence of censored data. To adjust for censoring, we propose a...

Supplement to “Q- and A-learning Methods for Estimating Optimal Dynamic Treatment Regimes”

A Smoothed Q-Learning Algorithm for Estimating Optimal Dynamic Treatment Regimes∗

In this paper we propose a smoothed Q-learning algorithm for estimating optimal dynamic treatment regimes. In contrast to the Q-learning algorithm in which non-regular inference is involved, we show that under assumptions adopted in this paper, the proposed smoothed Q-learning estimator is asymptotically normally distributed even when the Q-learning estimator is not and its asymptotic variance ...

Q- and A-learning Methods for Estimating Optimal Dynamic Treatment Regimes

In clinical practice, physicians make a series of treatment decisions over the course of a patient's disease based on his/her baseline and evolving characteristics. A dynamic treatment regime is a set of sequential decision rules that operationalizes this process. Each rule corresponds to a decision point and dictates the next treatment action based on the accrued information. Using existing da...